Howell Leung
SEEK ID: http://besttreat.hki-jena.de/people/1
Location:
DE
Expertise: Not specified
Tools: Not specified
ORCID: Not specified
Howell's tagsWP4 - Big data analysis of the gut microbiome (Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)) ; WP8 - Open Research Data (Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)) ; WP6 - Network, Local and External Training (Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)) ; WP5 - Phenotyping, engineering and characterisation (Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)) ; WP1 - Coordination and Project Management (Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)) ; WP7 - Dissemination, Exploitation and Communication (Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)) ; WP7-Sub Project: Communication and outreach activities (Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)) ; WP2 - Human cohorts and mice models (Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI)) ; WP3 - Mechanistic studies of microbiome-host interactions (Leibniz-Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI))
Related items
Objectives: Explore the predictive role of cytokines like adiponectin and the ratio of adiponectin for the prognosis of NAFLD. Identify the mechanisms of exercise-responsive gut microbiota mediated improvement in NAFLD.
Public web page: Not specified
Start date: 1st Sep 2018
End date: 31st Aug 2022
Objectives: Investigate the association between gut microbiota and NAFLD using a biobank from a cross-sectional and prospective study. Explore the predictive role of baseline gut microbiota for the prognosis of NAFLD. Compare the clinical effects under different intensity of exercise. Explore the role of gut microbiota in progression of NAFLD. Explore the mechanisms of certain key functional strains in the NAFLD improvement.
Public web page: Not specified
Start date: 1st Sep 2018
End date: 31st Aug 2022
Overall management of the project and communication with the EC.
Public web page: Not specified
Start date: 1st Sep 2018
End date: 31st Aug 2022
Objectives: To make BestTreat research data findable, accessible, interoperable and re-usable (FAIR).
Public web page: Not specified
Start date: 1st Sep 2018
End date: 31st Aug 2022
Public web page: Not specified
Start date: 16th Sep 2019
End date: 31st Aug 2022
See “List of identified sterols, bile acids, and acylcarnitines” for details.
Figure 1: Separation of the different classes of standards (sterols, bile acids, and acylcarnitines) based on retention time in reversed-phase liquid chromatography in the positive ionization mode.
Figure 2: Extracted ion chromatograms of the base peak spectra of detected sterols acquired from reference “BACSMLS” standards in the positive ionization mode. Peak identities are as follows: (1) cortisone, (2) corticosterone,
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Creator: Howell Leung
Contributor: Howell Leung
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Objective: The aim of this study was to present and validate a sensitive and simple liquid chromatography–tandem mass spectrometry (LC–MS/MS) method to detect the presence and distribution of NAFLD-related metabolites (sterols, bile acids, and acylcarnitines) in biological samples. These compound classes were considered as they are implicated in the development and progression of NAFLD; their detection by MS-based analytics is challenging due to the occurrence of many isomers and stereoisomers;
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Creator: Howell Leung
Contributor: Howell Leung
Abstract (Expand)
Authors: A. F. Babu, V. M. Koistinen, S. Turunen, G. Solano-Aguilar, J. F. Jr Urban, I. Zarei, K. Hanhineva
Date Published: 7th Jan 2022
Journal: Metabolites
Abstract (Expand)
Authors: I. Zarei, V. M. Koistinen, M. Kokla, A. Klavus, Ambrin Farizah Babu, M. Lehtonen, S. Auriola, K. Hanhineva
Date Published: 2nd Sep 2022
Journal: Sci Rep
Abstract (Expand)
Authors: Veera Houttu, J. Bouts, Y. Vali, J. Daams, A. Grefhorst, M. Nieuwdorp, A. G. Holleboom
Date Published: 21st Nov 2022
Journal: Front Endocrinol (Lausanne)
Abstract (Expand)
Authors: Ambrin Farizah Babu, Susanne Csader, V. Mannisto, M. M. Tauriainen, H. Pentikainen, K. Savonen, A. Klavus, V. Koistinen, K. Hanhineva, Ursula Schwab
Date Published: 20th Apr 2022
Journal: Sci Rep
Abstract (Expand)
Authors: Ambrin Farizah Babu, Susanne Csader, Johnson Lok, C. Gomez-Gallego, K. Hanhineva, H. El-Nezami, Ursula Schwab
Date Published: 8th Sep 2021
Journal: Nutrients
