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Mining, analyzing, and integrating viral signals from metagenomic data.

WP4 - Big data analysis of the gut microbiome

Abstract (Expand)

BACKGROUND: Viruses are important components of microbial communities modulating community structure and function; however, only a couple of tools are currently available for phage identification and ...

Authors: T. Zheng, J. Li, Y. Ni, K. Kang, M. A. Misiakou, L. Imamovic, B. K. C. Chow, A. A. Rode, P. Bytzer, M. Sommer, G. Panagiotou

Date Published: 19th Mar 2019

Journal: Microbiome

PubMed ID: 30890181

Citation: Microbiome. 2019 Mar 19;7(1):42. doi: 10.1186/s40168-019-0657-y.

Created: 29th Mar 2021 at 10:07

Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention.

WP4 - Big data analysis of the gut microbiome

Abstract (Expand)

Exercise is an effective strategy for diabetes management but is limited by the phenomenon of exercise resistance (i.e., the lack of or the adverse response to exercise on metabolic health). Here, in ...

Authors: Y. Liu, Y. Wang, Y. Ni, C. K. Y. Cheung, K. S. L. Lam, Y. Wang, Z. Xia, D. Ye, J. Guo, M. A. Tse, G. Panagiotou, A. Xu

Date Published: 7th Jan 2020

Journal: Cell Metab

PubMed ID: 31786155

Citation: Cell Metab. 2020 Jan 7;31(1):77-91.e5. doi: 10.1016/j.cmet.2019.11.001. Epub 2019 Nov 27.

Created: 29th Mar 2021 at 10:08

The role of the gut microbiome and exercise in non-alcoholic fatty liver disease.

WP2 - Human cohorts and mice models, WP4 - Big data analysis of the gut microbiome

Abstract (Expand)

In recent years, the human gut microbiome has been found to influence a multitude of non-communicable diseases such as cardiovascular disease and metabolic syndrome, with its components type 2 diabetes ...

Authors: Veera Houttu, Ulrika Boulund, A. Grefhorst, M. R. Soeters, S. J. Pinto-Sietsma, M. Nieuwdorp, A. G. Holleboom

Date Published: 25th Sep 2020

Journal: Therap Adv Gastroenterol

PubMed ID: 32973925

Citation: Therap Adv Gastroenterol. 2020 Sep 15;13:1756284820941745. doi: 10.1177/1756284820941745. eCollection 2020.

Created: 29th Mar 2021 at 10:09

Decreased Abundance of Akkermansia muciniphila Leads to the Impairment of Insulin Secretion and Glucose Homeostasis in Lean Type 2 Diabetes.

WP7 - Dissemination, Exploitation and Communication

Abstract (Expand)

Although obesity occurs in most of the patients with type 2 diabetes (T2D), a fraction of patients with T2D are underweight or have normal weight. Several studies have linked the gut microbiome to ...

Authors: J. Zhang, Y. Ni, L. Qian, Q. Fang, T. Zheng, M. Zhang, Q. Gao, Y. Zhang, J. Ni, X. Hou, Y. Bao, P. Kovatcheva-Datchary, A. Xu, H. Li, G. Panagiotou, W. Jia

Date Published: 4th Jun 2021

Journal: Adv Sci (Weinh)

PubMed ID: 34085773

Citation: Adv Sci (Weinh). 2021 Jun 4:e2100536. doi: 10.1002/advs.202100536.

Created: 22nd Jun 2021 at 11:52

Role of microbiota and related metabolites in gastrointestinal tract barrier function in NAFLD.

WP7 - Dissemination, Exploitation and Communication

Abstract (Expand)

The Gastrointestinal (GI) tract is composed of four main barriers: microbiological, chemical, physical and immunological. These barriers play important roles in maintaining GI tract homeostasis. In the ...

Authors: M. V. Fernandez-Cantos, Johnson Lok, Valeria Iannone, H. El-Nezami, M. Kolehmainen, O. P. Kuipers

Date Published: 19th Jul 2021

Journal: Tissue Barriers

PubMed ID: 34280073

Citation: Tissue Barriers. 2021 Jul 19:1879719. doi: 10.1080/21688370.2021.1879719.

Created: 2nd Sep 2021 at 08:30

Dietary Interventions in Patients With Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.

WP7 - Dissemination, Exploitation and Communication

(Show All)

Abstract (Expand)

Background: With no approved pharmacotherapy to date, the present therapeutic cornerstone for non-alcoholic fatty liver diseases (NAFLD) is a lifestyle intervention. Guidelines endorse weight loss ...

Authors: Veera Houttu, Susanne Csader, M. Nieuwdorp, A. G. Holleboom, Ursula Schwab

Date Published: 9th Aug 2021

Journal: Front Nutr

PubMed ID: 34368214

Citation: Front Nutr. 2021 Jul 22;8:716783. doi: 10.3389/fnut.2021.716783. eCollection 2021.

Created: 2nd Sep 2021 at 08:32

Decreased Abundance of Akkermansia muciniphila Leads to the Impairment of Insulin Secretion and Glucose Homeostasis in Lean Type 2 Diabetes.

WP4 - Big data analysis of the gut microbiome

Abstract (Expand)

Authors: J. Zhang, Y. Ni, L. Qian, Q. Fang, T. Zheng, M. Zhang, Q. Gao, Y. Zhang, J. Ni, X. Hou, Y. Bao, P. Kovatcheva-Datchary, A. Xu, H. Li, G. Panagiotou, W. Jia

Date Published: 5th Jun 2021

Journal: Adv Sci (Weinh)

PubMed ID: 34085773

Citation: Adv Sci (Weinh). 2021 Aug;8(16):e2100536. doi: 10.1002/advs.202100536. Epub 2021 Jun 4.

Created: 22nd Nov 2022 at 09:37

Risk assessment with gut microbiome and metabolite markers in NAFLD development.

WP4 - Big data analysis of the gut microbiome, WP7 - Dissemination, Exploitation and Communication

(Show All)

Abstract (Expand)

A growing body of evidence suggests interplay between the gut microbiota and the pathogenesis of nonalcoholic fatty liver disease (NAFLD). However, the role of the gut microbiome in early detection of ...

Authors: Howell Leung, X. Long, Y. Ni, L. Qian, Manos Nychas, Sara Leal Siliceo, Dennis Pohl, K. Hanhineva, Y. Liu, A. Xu, H. B. Nielsen, E. Belda, K. Clement, R. Loomba, H. Li, W. Jia, G. Panagiotou

Date Published: 8th Jun 2022

Journal: Sci Transl Med

PubMed ID: 35675435

Citation: Sci Transl Med. 2022 Jun 8;14(648):eabk0855. doi: 10.1126/scitranslmed.abk0855. Epub 2022 Jun 8.

Created: 22nd Nov 2022 at 09:47

Physical Activity and Dietary Composition Relate to Differences in Gut Microbial Patterns in a Multi-Ethnic Cohort-The HELIUS Study.

WP4 - Big data analysis of the gut microbiome, WP7 - Dissemination, Exploitation and Communication

Abstract (Expand)

Physical activity (PA) at recommended levels contributes to the prevention of non-communicable diseases, such as atherosclerotic cardiovascular disease (asCVD) and type 2 diabetes mellitus (T2DM). Since ...

Authors: Veera Houttu, Ulrika Boulund, M. Nicolaou, A. G. Holleboom, A. Grefhorst, H. Galenkamp, B. J. van den Born, K. Zwinderman, M. Nieuwdorp

Date Published: 9th Dec 2021

Journal: Metabolites

PubMed ID: 34940616

Citation: Metabolites. 2021 Dec 9;11(12). pii: metabo11120858. doi: 10.3390/metabo11120858.

Created: 22nd Nov 2022 at 09:52

Effects of broad-spectrum antibiotics on the colonisation of probiotic yeast Saccharomyces boulardii in the murine gastrointestinal tract.

WP5 - Phenotyping, engineering and characterisation, WP7 - Dissemination, Exploitation and Communication

Abstract (Expand)

Mouse models are commonly used to study the colonisation profiles of microorganisms introduced to the gastrointestinal tract. Three commonly used mouse models include conventional, germ-free, and ...

Authors: Alex Hedin, V. E. Rees, H. Zhang, V. Kruse, R. Vazquez-Uribe, M. O. A. Sommer

Date Published: 25th May 2022

Journal: Sci Rep

PubMed ID: 35614092

Citation: Sci Rep. 2022 May 25;12(1):8862. doi: 10.1038/s41598-022-12806-0.

Created: 22nd Nov 2022 at 10:05

Evaluation of Caco-2 and human intestinal epithelial cells as in vitro models of colonic and small intestinal integrity.

WP5 - Phenotyping, engineering and characterisation, WP7 - Dissemination, Exploitation and Communication

Abstract (Expand)

Although the colonic cell line Caco-2 is widely used as a model of the small intestinal barrier function, it has limitations such as overestimated transepithelial electrical resistance (TEER) compared ...

Authors: S. Lopez-Escalera, A. Wellejus

Date Published: 25th Jul 2022

Journal: Biochem Biophys Rep

PubMed ID: 35873654

Citation: Biochem Biophys Rep. 2022 Jul 18;31:101314. doi: 10.1016/j.bbrep.2022.101314. eCollection 2022 Sep.

Created: 22nd Nov 2022 at 10:07

Positive Effects of Exercise Intervention without Weight Loss and Dietary Changes in NAFLD-Related Clinical Parameters: A Systematic Review and Meta-Analysis.

WP7 - Dissemination, Exploitation and Communication

(Show All)

Abstract (Expand)

One of the focuses of non-alcoholic fatty liver disease (NAFLD) treatment is exercise. Randomized controlled trials investigating the effects of exercise without dietary changes on NAFLD-related clinical ...

Authors: Ambrin Farizah Babu, Susanne Csader, Johnson Lok, C. Gomez-Gallego, K. Hanhineva, H. El-Nezami, Ursula Schwab

Date Published: 8th Sep 2021

Journal: Nutrients

PubMed ID: 34579012

Citation: Nutrients. 2021 Sep 8;13(9). pii: nu13093135. doi: 10.3390/nu13093135.

Created: 22nd Nov 2022 at 10:21

Effects of exercise on NAFLD using non-targeted metabolomics in adipose tissue, plasma, urine, and stool.

WP7 - Dissemination, Exploitation and Communication

(Show All)

Abstract (Expand)

The mechanisms by which exercise benefits patients with non-alcoholic fatty liver disease (NAFLD), the most common liver disease worldwide, remain poorly understood. A non-targeted liquid chromatography-mass ...

Authors: Ambrin Farizah Babu, Susanne Csader, V. Mannisto, M. M. Tauriainen, H. Pentikainen, K. Savonen, A. Klavus, V. Koistinen, K. Hanhineva, Ursula Schwab

Date Published: 20th Apr 2022

Journal: Sci Rep

PubMed ID: 35444259

Citation: Sci Rep. 2022 Apr 20;12(1):6485. doi: 10.1038/s41598-022-10481-9.

Created: 22nd Nov 2022 at 10:23

Does aerobic exercise reduce NASH and liver fibrosis in patients with non-alcoholic fatty liver disease? A systematic literature review and meta-analysis.

WP7 - Dissemination, Exploitation and Communication

Abstract (Expand)

Background: Exercise is an effective strategy for the prevention and regression of hepatic steatosis in patients with non-alcoholic fatty liver disease (NAFLD), but it is unclear whether it can reduce ...

Authors: Veera Houttu, J. Bouts, Y. Vali, J. Daams, A. Grefhorst, M. Nieuwdorp, A. G. Holleboom

Date Published: 21st Nov 2022

Journal: Front Endocrinol (Lausanne)

PubMed ID: 36407307

Citation: Front Endocrinol (Lausanne). 2022 Nov 3;13:1032164. doi: 10.3389/fendo.2022.1032164. eCollection 2022.

Created: 22nd Nov 2022 at 10:25

Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition.

WP4 - Big data analysis of the gut microbiome, WP7 - Dissemination, Exploitation and Communication

Abstract (Expand)

The essential role of gut microbiota in health and disease is well recognized, but the biochemical details that underlie the beneficial impact remain largely undefined. To maintain its stability, ...

Authors: I. Zarei, V. M. Koistinen, M. Kokla, A. Klavus, Ambrin Farizah Babu, M. Lehtonen, S. Auriola, K. Hanhineva

Date Published: 2nd Sep 2022

Journal: Sci Rep

PubMed ID: 36056162

Citation: Sci Rep. 2022 Sep 2;12(1):15018. doi: 10.1038/s41598-022-19327-w.

Created: 22nd Nov 2022 at 10:26

Identification and Distribution of Sterols, Bile Acids, and Acylcarnitines by LC-MS/MS in Humans, Mice, and Pigs-A Qualitative Analysis.

WP7 - Dissemination, Exploitation and Communication

Abstract (Expand)

Sterols, bile acids, and acylcarnitines are key players in human metabolism. Precise annotations of these metabolites with mass spectrometry analytics are challenging because of the presence of several ...

Authors: A. F. Babu, V. M. Koistinen, S. Turunen, G. Solano-Aguilar, J. F. Jr Urban, I. Zarei, K. Hanhineva

Date Published: 7th Jan 2022

Journal: Metabolites

PubMed ID: 35050171

Citation: Metabolites. 2022 Jan 7;12(1). pii: metabo12010049. doi: 10.3390/metabo12010049.

Created: 22nd Nov 2022 at 10:33